Management of lung transplantation in the COVID-19 era-An international survey.
Identifieur interne : 000347 ( Main/Exploration ); précédent : 000346; suivant : 000348Management of lung transplantation in the COVID-19 era-An international survey.
Auteurs : Benjamin Coiffard [France] ; Philipp M. Lepper [Allemagne] ; Eloi Prud'Homme [France] ; Florence Daviet [France] ; Nadim Cassir [France] ; Heinrike Wilkens [Allemagne] ; Sami Hraiech [France] ; Frank Langer [Allemagne] ; Pascal A. Thomas [France] ; Martine Reynaud-Gaubert [France] ; Robert Bals [Allemagne] ; Hans-Joachim Sch Fers [Allemagne] ; Laurent Papazian [France] ; Frederik Seiler [Allemagne]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2021.
Descripteurs français
- KwdFr :
- MESH :
- usage thérapeutique : Immunosuppresseurs.
- Facteurs de risque, Humains, Listes d'attente, Pandémies, Receveurs de transplantation, Transplantation pulmonaire.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Immunosuppressive Agents.
- diagnosis : COVID-19.
- therapy : COVID-19.
- Humans, Lung Transplantation, Pandemics, Risk Factors, Transplant Recipients, Waiting Lists.
Abstract
It is unknown if solid organ transplant recipients are at higher risk for severe COVID-19. The management of a lung transplantation (LTx) program and the therapeutic strategies to adapt the immunosuppressive regimen and antiviral measures is a major issue in the COVID-19 era, but little is known about worldwide practice. We sent out to 180 LTx centers worldwide in June 2020 a survey with 63 questions, both regarding the management of a LTx program in the COVID-19 era and the therapeutic strategies to treat COVID-19 LTx recipients. We received a total of 78 responses from 15 countries. Among participants, 81% declared a reduction of the activity and 47% restricted LTx for urgent cases only. Sixteen centers observed deaths on waiting listed patients and eight centers performed LTx for COVID-19 disease. In 62% of the centers, COVID-19 was diagnosed in LTx recipients, most of them not severe cases. The most common immunosuppressive management included a decreased dose or pausing of the cell cycle inhibitors. Remdesivir, hydroxychloroquine, and azithromycin were the most proposed antiviral strategies. Most of the centers have been affected by the COVID-19 pandemic and proposed an active therapeutic strategy to treat LTx recipients with COVID-19.
DOI: 10.1111/ajt.16368
PubMed: 33084144
Affiliations:
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Thomas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Thoracic Surgery, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Thoracic Surgery, Aix Marseille Univ, APHM, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Reynaud Gaubert, Martine" sort="Reynaud Gaubert, Martine" uniqKey="Reynaud Gaubert M" first="Martine" last="Reynaud-Gaubert">Martine Reynaud-Gaubert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Bals, Robert" sort="Bals, Robert" uniqKey="Bals R" first="Robert" last="Bals">Robert Bals</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Sch Fers, Hans Joachim" sort="Sch Fers, Hans Joachim" uniqKey="Sch Fers H" first="Hans-Joachim" last="Sch Fers">Hans-Joachim Sch Fers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Papazian, Laurent" sort="Papazian, Laurent" uniqKey="Papazian L" first="Laurent" last="Papazian">Laurent Papazian</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Seiler, Frederik" sort="Seiler, Frederik" uniqKey="Seiler F" first="Frederik" last="Seiler">Frederik Seiler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33084144</idno><idno type="pmid">33084144</idno><idno type="doi">10.1111/ajt.16368</idno><idno type="wicri:Area/Main/Corpus">000980</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000980</idno><idno type="wicri:Area/Main/Curation">000980</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000980</idno><idno type="wicri:Area/Main/Exploration">000980</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Management of lung transplantation in the COVID-19 era-An international survey.</title><author><name sortKey="Coiffard, Benjamin" sort="Coiffard, Benjamin" uniqKey="Coiffard B" first="Benjamin" last="Coiffard">Benjamin Coiffard</name><affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Lepper, Philipp M" sort="Lepper, Philipp M" uniqKey="Lepper P" first="Philipp M" last="Lepper">Philipp M. Lepper</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Prud Homme, Eloi" sort="Prud Homme, Eloi" uniqKey="Prud Homme E" first="Eloi" last="Prud'Homme">Eloi Prud'Homme</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Daviet, Florence" sort="Daviet, Florence" uniqKey="Daviet F" first="Florence" last="Daviet">Florence Daviet</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Cassir, Nadim" sort="Cassir, Nadim" uniqKey="Cassir N" first="Nadim" last="Cassir">Nadim Cassir</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Wilkens, Heinrike" sort="Wilkens, Heinrike" uniqKey="Wilkens H" first="Heinrike" last="Wilkens">Heinrike Wilkens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Hraiech, Sami" sort="Hraiech, Sami" uniqKey="Hraiech S" first="Sami" last="Hraiech">Sami Hraiech</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Langer, Frank" sort="Langer, Frank" uniqKey="Langer F" first="Frank" last="Langer">Frank Langer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Pascal A" sort="Thomas, Pascal A" uniqKey="Thomas P" first="Pascal A" last="Thomas">Pascal A. Thomas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Thoracic Surgery, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Thoracic Surgery, Aix Marseille Univ, APHM, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Reynaud Gaubert, Martine" sort="Reynaud Gaubert, Martine" uniqKey="Reynaud Gaubert M" first="Martine" last="Reynaud-Gaubert">Martine Reynaud-Gaubert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Bals, Robert" sort="Bals, Robert" uniqKey="Bals R" first="Robert" last="Bals">Robert Bals</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Sch Fers, Hans Joachim" sort="Sch Fers, Hans Joachim" uniqKey="Sch Fers H" first="Hans-Joachim" last="Sch Fers">Hans-Joachim Sch Fers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Papazian, Laurent" sort="Papazian, Laurent" uniqKey="Papazian L" first="Laurent" last="Papazian">Laurent Papazian</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Seiler, Frederik" sort="Seiler, Frederik" uniqKey="Seiler F" first="Frederik" last="Seiler">Frederik Seiler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>COVID-19 (diagnosis)</term><term>COVID-19 (therapy)</term><term>Humans (MeSH)</term><term>Immunosuppressive Agents (therapeutic use)</term><term>Lung Transplantation (MeSH)</term><term>Pandemics (MeSH)</term><term>Risk Factors (MeSH)</term><term>Transplant Recipients (MeSH)</term><term>Waiting Lists (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Facteurs de risque (MeSH)</term><term>Humains (MeSH)</term><term>Immunosuppresseurs (usage thérapeutique)</term><term>Listes d'attente (MeSH)</term><term>Pandémies (MeSH)</term><term>Receveurs de transplantation (MeSH)</term><term>Transplantation pulmonaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunosuppresseurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Lung Transplantation</term><term>Pandemics</term><term>Risk Factors</term><term>Transplant Recipients</term><term>Waiting Lists</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term><term>Humains</term><term>Listes d'attente</term><term>Pandémies</term><term>Receveurs de transplantation</term><term>Transplantation pulmonaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is unknown if solid organ transplant recipients are at higher risk for severe COVID-19. The management of a lung transplantation (LTx) program and the therapeutic strategies to adapt the immunosuppressive regimen and antiviral measures is a major issue in the COVID-19 era, but little is known about worldwide practice. We sent out to 180 LTx centers worldwide in June 2020 a survey with 63 questions, both regarding the management of a LTx program in the COVID-19 era and the therapeutic strategies to treat COVID-19 LTx recipients. We received a total of 78 responses from 15 countries. Among participants, 81% declared a reduction of the activity and 47% restricted LTx for urgent cases only. Sixteen centers observed deaths on waiting listed patients and eight centers performed LTx for COVID-19 disease. In 62% of the centers, COVID-19 was diagnosed in LTx recipients, most of them not severe cases. The most common immunosuppressive management included a decreased dose or pausing of the cell cycle inhibitors. Remdesivir, hydroxychloroquine, and azithromycin were the most proposed antiviral strategies. Most of the centers have been affected by the COVID-19 pandemic and proposed an active therapeutic strategy to treat LTx recipients with COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">33084144</PMID><DateCompleted><Year>2021</Year><Month>04</Month><Day>27</Day></DateCompleted><DateRevised><Year>2021</Year><Month>04</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>4</Issue><PubDate><Year>2021</Year><Month>04</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>Management of lung transplantation in the COVID-19 era-An international survey.</ArticleTitle><Pagination><MedlinePgn>1586-1596</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.16368</ELocationID><Abstract><AbstractText>It is unknown if solid organ transplant recipients are at higher risk for severe COVID-19. The management of a lung transplantation (LTx) program and the therapeutic strategies to adapt the immunosuppressive regimen and antiviral measures is a major issue in the COVID-19 era, but little is known about worldwide practice. We sent out to 180 LTx centers worldwide in June 2020 a survey with 63 questions, both regarding the management of a LTx program in the COVID-19 era and the therapeutic strategies to treat COVID-19 LTx recipients. We received a total of 78 responses from 15 countries. Among participants, 81% declared a reduction of the activity and 47% restricted LTx for urgent cases only. Sixteen centers observed deaths on waiting listed patients and eight centers performed LTx for COVID-19 disease. In 62% of the centers, COVID-19 was diagnosed in LTx recipients, most of them not severe cases. The most common immunosuppressive management included a decreased dose or pausing of the cell cycle inhibitors. Remdesivir, hydroxychloroquine, and azithromycin were the most proposed antiviral strategies. Most of the centers have been affected by the COVID-19 pandemic and proposed an active therapeutic strategy to treat LTx recipients with COVID-19.</AbstractText><CopyrightInformation>© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Coiffard</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0002-8896-5346</Identifier><AffiliationInfo><Affiliation>Department of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lepper</LastName><ForeName>Philipp M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prud'Homme</LastName><ForeName>Eloi</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daviet</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cassir</LastName><ForeName>Nadim</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilkens</LastName><ForeName>Heinrike</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hraiech</LastName><ForeName>Sami</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langer</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Pascal A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Department of Thoracic Surgery, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reynaud-Gaubert</LastName><ForeName>Martine</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bals</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schäfers</LastName><ForeName>Hans-Joachim</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papazian</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seiler</LastName><ForeName>Frederik</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016040" MajorTopicYN="Y">Lung Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066027" MajorTopicYN="N">Transplant Recipients</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014850" MajorTopicYN="N">Waiting Lists</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">antibiotic: antiviral</Keyword><Keyword MajorTopicYN="Y">clinical research / practice</Keyword><Keyword MajorTopicYN="Y">immunosuppression / immune modulation</Keyword><Keyword MajorTopicYN="Y">immunosuppressive regimens</Keyword><Keyword MajorTopicYN="Y">infection and infectious agents - viral</Keyword><Keyword MajorTopicYN="Y">infectious disease</Keyword><Keyword MajorTopicYN="Y">lung transplantation / pulmonology</Keyword><Keyword MajorTopicYN="Y">recipient selection</Keyword><Keyword MajorTopicYN="Y">waitlist management</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>10</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>10</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>4</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>9</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33084144</ArticleId><ArticleId IdType="doi">10.1111/ajt.16368</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>WHO: Rolling Updates on Coronavirus Disease (COVID-19). https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen. 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Transplant direct. 2020;6(6):e554.</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Coiffard, Benjamin" sort="Coiffard, Benjamin" uniqKey="Coiffard B" first="Benjamin" last="Coiffard">Benjamin Coiffard</name></region><name sortKey="Cassir, Nadim" sort="Cassir, Nadim" uniqKey="Cassir N" first="Nadim" last="Cassir">Nadim Cassir</name><name sortKey="Daviet, Florence" sort="Daviet, Florence" uniqKey="Daviet F" first="Florence" last="Daviet">Florence Daviet</name><name sortKey="Hraiech, Sami" sort="Hraiech, Sami" uniqKey="Hraiech S" first="Sami" last="Hraiech">Sami Hraiech</name><name sortKey="Papazian, Laurent" sort="Papazian, Laurent" uniqKey="Papazian L" first="Laurent" last="Papazian">Laurent Papazian</name><name sortKey="Prud Homme, Eloi" sort="Prud Homme, Eloi" uniqKey="Prud Homme E" first="Eloi" last="Prud'Homme">Eloi Prud'Homme</name><name sortKey="Reynaud Gaubert, Martine" sort="Reynaud Gaubert, Martine" uniqKey="Reynaud Gaubert M" first="Martine" last="Reynaud-Gaubert">Martine Reynaud-Gaubert</name><name sortKey="Thomas, Pascal A" sort="Thomas, Pascal A" uniqKey="Thomas P" first="Pascal A" last="Thomas">Pascal A. Thomas</name></country><country name="Allemagne"><noRegion><name sortKey="Lepper, Philipp M" sort="Lepper, Philipp M" uniqKey="Lepper P" first="Philipp M" last="Lepper">Philipp M. Lepper</name></noRegion><name sortKey="Bals, Robert" sort="Bals, Robert" uniqKey="Bals R" first="Robert" last="Bals">Robert Bals</name><name sortKey="Langer, Frank" sort="Langer, Frank" uniqKey="Langer F" first="Frank" last="Langer">Frank Langer</name><name sortKey="Sch Fers, Hans Joachim" sort="Sch Fers, Hans Joachim" uniqKey="Sch Fers H" first="Hans-Joachim" last="Sch Fers">Hans-Joachim Sch Fers</name><name sortKey="Seiler, Frederik" sort="Seiler, Frederik" uniqKey="Seiler F" first="Frederik" last="Seiler">Frederik Seiler</name><name sortKey="Wilkens, Heinrike" sort="Wilkens, Heinrike" uniqKey="Wilkens H" first="Heinrike" last="Wilkens">Heinrike Wilkens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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